Huvec Cell Culture

Myocyte

Neuroblastoma

Macrophage

FIGURE 5.5. Schematic of a potential multi-phenotypic biosensor. Six different cell lines are isolated in hydrogel arrays in six different microfluidic channels. Several cellular assays can be performed using one array.

Multi-phenotypic arrays offer the advantage of providing more information about cellular responses than existing arrays and lend themselves to miniaturization, which could lead to high degrees of multiplexing. Multi-phenotypic cell based biosensors show promise in the area of high-throughput drug screening, the detection of biochemical warfare agents, and the detection of environmental toxins. While the use of nucleic acid and protein arrays is well established, the uses of multi-phenotypic cellular arrays are in the infancy of their development, creating an exciting and dynamic area of research.

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