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polymer nanofibers

eSpin

SBIR and STTR funding can accelerate the transformation of the existing science discovery into technology ready for commercial attention.

Mid-term (5-10-Year) Transition Opportunities

Those areas where an investment in nanoscience holds the promise for paradigm-breaking approaches to detection/protection/neutralization with commercial product transition in the 5-10 year timeframe include the following:

Sensing

• transduction/actuation mechanisms for greater sensitivity/selectivity

• biotic/abiotic interfaces to marry semiconductors with in-vivo biology

• environmental energy sources to minimize battery requirements Protection

• high-surface-area materials with templated structure for selective adsorption

- controlled porosity for separation

- nanofibers for clothing with improved adsorption/neutralization of agent

• neutralization/decontamination

- nanostructures to disrupt biological function

- catalytic nanostructures

• Therapeutics

- Encapsulated drugs for targeted release

- MEMS "capsules" for controlled drug release Long-Term (10-20-Year) Transition Opportunities

Investment in the science base long-term is believed to be important for ultimate integration of many components into a complex system (e.g., sensor suites) and for providing sufficient insights into a complex system (e.g., cell and spore physiology) to enable innovative technologies. Examples include

• Laboratory on a chip — incorporation of multiple separation and detection technologies at submicron scales on a single chip in order to obtain inexpensive, rapid detection technology with low false positive/negative events

• Cell-based sensing — development of sensing technology that responds to unknown new threats by measuring the response of living systems that can mimic human biochemistry

• Nanoelectromechanical systems (NEMS) — extension of the MEMS technologies another three orders smaller in order to incorporate significantly more capability

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