Dna

Tablet

Micro spheres

Dendrimer

Dendrimer

Figure 5.1. Progress of drug delivery from "macro" systems that interact at the organ level to "micro" systems that interact at the cellular level to "nano" systems that interact at the cellular level. Length scale has a significant influence on drug delivery in terms of reaching the target site, modifying the biodistribution of the drug, and enhancing the efficacy of the drug.

Figure 5.1. Progress of drug delivery from "macro" systems that interact at the organ level to "micro" systems that interact at the cellular level to "nano" systems that interact at the cellular level. Length scale has a significant influence on drug delivery in terms of reaching the target site, modifying the biodistribution of the drug, and enhancing the efficacy of the drug.

Figure 5.6. Confocal images showing lung epithelial cells. (a) Under phase contrast. (b) Localization of FITC-labeled PAMAM G4 hydroxyl terminated dendrimer in the cytoplasm. (c) Localization of lysosomal marker (lysotracker) in the lysosomes. (d) Co-localization of FITC-labeled dendrimer and lysostracker in the lysosomes. Images were captured 30min after treatment.

Figure 5.6. Confocal images showing lung epithelial cells. (a) Under phase contrast. (b) Localization of FITC-labeled PAMAM G4 hydroxyl terminated dendrimer in the cytoplasm. (c) Localization of lysosomal marker (lysotracker) in the lysosomes. (d) Co-localization of FITC-labeled dendrimer and lysostracker in the lysosomes. Images were captured 30min after treatment.

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