An interesting condensation has been reported in which a 2-pyridyl-1,3-butanedione (53a) reacts with ,3-aminoacrylonitrile (54) to provide 3-cyano-4-(trifluoromethyl)tpy (55) in 30% yield (Scheme 10).57 The reaction has been used employing a wide variety of partners besides those involving 2-pyridyl. The Hantzsch approach has been used in the reaction of keto-ester (53b) with enone (56) to provide (57), where the 2-furfuryl group may be oxidized under mild conditions to provide the 3',4'-tpy dicarboxylic acid.58

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