Active Targeting Strategies in Cancer with a Focus on Potential Nanotechnology Applications

Randall J. Mrsny

3.1 Introduction 19

3.2 Nanoparticle Characteristics 20

3.2.1 Composition and Biocompatibility 22

3.2.2 Derivitization 23

3.2.3 Detection 23

3.3 Nanoparticle Targeting 24

3.3.1 Inherent Targeting 24

3.3.2 Complicating Aspects 25

3.3.3 Safety Issues 26

3.4 Targeting to Cancer Cells 27

3.4.1 Cell Surface Properties 28

3.4.2 Metabolic Properties 29

3.5 Targeting to Tumors 30

3.5.1 Aberrant Vasculature 30

3.5.2 Metabolic Environment 32

3.6 Fate of Nanoparticles 32

3.6.1 Site of Initial Application 33

3.6.2 Distribution to Specific Organs 34

3.6.3 Intracellular Uptake and Fate 34

3.7 Conclusions 35

References 37

CONTENTS

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