Boron Delivery by Targeted Liposomes

To improve the specificity of liposomally encapsulated drugs and to increase the amount of boron delivered, targeting moieties have been attached to the surface of liposomes. These could be any molecules that selectively recognized and bound to target antigens or receptors that were over expressed on neoplastic cells or tumor-associated neovasculature. These have included either intact mAb molecules or fragments, LMW, naturally occurring or synthetic ligands such as peptides or receptor-binding-ligands such as EGF. To date, liposomes linked to mAbs or their fragments,129

130 131 112

EGF, folate, and transferin, have been the most extensively studied as targeting moieties (Figure 6.8).

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