Cationic Liposomes for Lung Targeting

After intravenous administration of pDNA complex, the immediate effect on the complex of erythrocytes is to induce aggregation.88 Large aggregates (> 400 nm) may be readily entrapped in the lung capillary. Mahato et al. demonstrated that cationic liposome/[32P] pDNA complexes (lipoplexes) were rapidly cleared from the blood circulation and accumulated extensively in the lung and liver.89 In addition, [32P] lipoplexes were predominantly taken up by the liver NPC and

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