Contents

9.1 Introduction 159

9.2 Tumor Angiogenesis 161

9.3 Angiogenesis Markers 162

9.3.1 VEGF and VEGF Receptors 162

9.3.2 Aminopeptidases 162

9.3.3 Matrix Metalloproteinases 164

9.3.4 Integrins 166

9.3.4.1 RGD Multimers 167

9.4 Polymeric Conjugates for Angiogenesis Targeting 168

9.4.1 Polymer-Based Antiangiogenic Gene Therapy 169

9.4.2 Polymer-Based Nuclear Imaging and Radiotherapy 170

9.5 Summary and Future Directions 175

9.6 List of Abbreviations 175

Acknowledgment 177

References 177

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