Contents

11.1 Introduction 201

11.2 Magnetic Resonance Imaging 202

11.2.1 Principles of MRI 202

11.2.2 Contrast-Enhanced MRI 203

11.3 MR Imaging of Paramagnetic HPMA Copolymer Conjugates 204

11.3.1 MR Imaging of a Paramagnetic HPMA Conjugate in an Animal

Tumor Model 204

11.3.2 MR Imaging of a Paramagnetic HPMA Conjugate for Bone Delivery 206

11.4 MR Imaging of Paramagnetic Poly(l-Glutamic Acid) Conjugates 206

11.4.1 MR Imaging of PGA-(Gd-DOTA) Conjugate in an Animal

Tumor Model 206

11.4.2 MR Imaging of PGA-Mce6-(Gd-DOTA) Conjugate in an Animal

Tumor Model 208

11.5 Summary 210

References 210

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