Contents

18.1 Introduction 358

18.2 Synthesis of PEO-b-PLAA Block Copolymers 358

18.3 Micellization of PEO-b-PLAA Block Copolymers 361

18.3.1 Dialysis Method 362

18.3.2 Solvent Evaporation Method 362

18.3.3 Co-Solvent Evaporation Method 362

18.4 Rational Design and Functional Properties of PEO-b-PLAA Micelles in

Drug Delivery 363

18.4.1 The PEO Shell 363

18.4.3 Micellar Dimensions 363

18.4.4 Micellar Stability 367

18.4.5 Drug Incorporation and Release Properties 368

18.5 PEO-b-PLAA Micelles for the Delivery of Anti-Cancer Drugs 369

18.5.1 Cyclophosphamide 369

18.5.2 Doxorubicin 369

18.5.3 Paclitaxel 370

18.5.4 Cisplatin and Its Derivative 370

18.5.5 Methotrexate 371

18.5.6 KRN5500 371

18.5.7 Camptothecin 372

18.6 PEO-b-PLAA Micelles for the Delivery of Other Therapeutic Agents 372

18.6.1 Amphotericin B 372

18.6.2 Indomethacin 373

18.7 PEO-b-PLAA Micelles for Active Drug Targeting 373

18.8 PEO-b-PLAA Micelles for Gene Delivery 374

References 376

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