Contents

12.1 Introduction 215

12.2 Targeting to Cancer 216

12.3 Passive Targeting and the EPR Effect 217

12.4 Targeting to Angiogenesis 218

12.4.1 Targeting Using Vascular Endothelial Growth Factor Receptors 218

12.4.2 Targeting Using Integrins 218

12.4.2.1 Integrins as Targets for Imaging 220

12.5 Targeting Using Folate Receptors 220

12.5.1 Antibodies and Folate Receptors 221

12.5.2 Folate-Targeted Nanoparticles for Gene Delivery 222

12.6 Approaches for Cancer Targeting to Specific Cancer Types 223

12.6.1 Prostate Cancer 224

12.7 Targeted Nanoparticles and Imaging of Cancer 225

12.8 Other Targets for Cancer 225

12.9 Avidin and Biotin Targeting 226

12.10 Conclusions 226

References 226

Diabetes Sustenance

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