Contents

10.1 Introduction 185

10.2 Synthesis and Properties of PG 186

10.2.1 Chemistry 186

10.2.2 Biodegradation and Biodistribution 187

10.3 PG-Anti-Cancer Drug Conjugates 187

10.3.1 Anthracyclines 187

10.3.2 Antimetabolites 188

10.3.3 DNA-Binding Drugs 188

10.4 PG-TXL and PG-CPT: From the Laboratory to the Clinic 189

10.4.1 PG-TXL 189

10.4.2 PG-CPT 192

10.5 Combination of PG-TXL with Radiotherapy 193

10.6 PG as a Carrier of Diagnostic Agents 193

10.6.1 Magnetic Resonance Imaging 193

10.6.2 Near-Infrared Fluorescence Optical Imaging 195

10.7 Conclusions 195

Acknowledgments 196

References 196

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