Drug Transport Vectors

One approach to improve brain tumor uptake of boron compounds has been to conjugate them to a drug-transport vector by means of receptor-specific transport systems.160,161 Proteins such as insulin, insulin-like growth factor (IGF), TF,162 and leptin can traverse the BBB. BSH encapsulated in TF_PEG liposomes had a prolonged residence time in the circulation and low RES uptake in tumor-bearing mice, resulting in enhanced extravasation of the liposomes into the tumor and concomitant internalization by receptor-mediated endocytosis.163,164 Mice that received BSH containing TF-liposomes following by BNCT had a significant prolongation in survival time compared to those that received PEG-liposomes, bare liposomes and free BSH, thereby establishing proof-of-principle for transcytosis of a boron containing nanovehicle.112

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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