Drug Transport Vectors

One approach to improve brain tumor uptake of boron compounds has been to conjugate them to a drug-transport vector by means of receptor-specific transport systems.160,161 Proteins such as insulin, insulin-like growth factor (IGF), TF,162 and leptin can traverse the BBB. BSH encapsulated in TF_PEG liposomes had a prolonged residence time in the circulation and low RES uptake in tumor-bearing mice, resulting in enhanced extravasation of the liposomes into the tumor and concomitant internalization by receptor-mediated endocytosis.163,164 Mice that received BSH containing TF-liposomes following by BNCT had a significant prolongation in survival time compared to those that received PEG-liposomes, bare liposomes and free BSH, thereby establishing proof-of-principle for transcytosis of a boron containing nanovehicle.112

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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