Effect of Modification for Cell Selective Delivery

Ligand modification for active targeting using receptor-mediated uptake markedly affects the pharmacokinetic properties of macromolecules.4 For example, pharmacokinetic studies of receptor-mediated targeting to liver parenchymal cells via galactose recognition have been carried out based on the clearance concept. Galactose modification increased the hepatic uptake of macromolecules of different molecular weights.3 The clearance was almost the same as the hepatic flow rate in mice, showing that it is almost identical to the theoretical maximum value.

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