Effect of Modification for Cell Selective Delivery

Ligand modification for active targeting using receptor-mediated uptake markedly affects the pharmacokinetic properties of macromolecules.4 For example, pharmacokinetic studies of receptor-mediated targeting to liver parenchymal cells via galactose recognition have been carried out based on the clearance concept. Galactose modification increased the hepatic uptake of macromolecules of different molecular weights.3 The clearance was almost the same as the hepatic flow rate in mice, showing that it is almost identical to the theoretical maximum value.

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment