Effect of Size on the Pharmacokinetic Properties

After intravenous injection, the kidney plays an important role in the disposition of macromolecules circulating in the blood. Macromolecules with a molecular weight of less than 50,000 (approximately 6 nm in diameter) are susceptible to glomerular filtration and are excreted in the urine.72-75 Therefore, low molecular weight drugs and oligonucleotides with a lower molecular weight undergo rapid glomerular filtration by the kidney.76,77 On the other hand, pDNA is too large to be filtered without degradation.78

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