EGFRTargeted Liposomes

Acridine is a WS, DNA-intercalator. Its boronated derivative WSA was incorporated into liposomes composed of EGF-conjugated lipids. Their surface contained approximately 5 mol% PEG and 10-15 molecules of EGF, and 104-105 of WSA molecules were encapsulated. These liposomes had EGFR-specific cellular binding to cultured human glioma cells130,140 and were internalized following specific binding to the receptor. Following internalization, WSA primarily was localized in the cytoplasm, and had high cellular retention with 80% of the boron remaining cell-associated after 48 h.141

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook

Post a comment