Human Epidermal Growth Factor3

Human epidermal growth factor-3 (HER-3) is a receptor tyrosine kinase that is over-expressed in several cancers. Over-expression of HER-3 is also associated with drug resistance in many HER-2 over-expressed tumors, making HER-3 a candidate target for drug delivery. A30 is an RNA aptamer that was isolated against the extracellular domain of the HER-3 and is shown to inhibit heregluin dependent tyrosine phosphorylation of HER-2 and heregluin-induced growth response of MCF-7 cells at Ki = 10 and 1 nM, respectively.57 The future use of A30 for in vivo application may require post-SELEX optimization of this aptamer, including nuclease stabilization and size minimization.

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