In Vivo Targeted Drug Delivery

System Method

EPR (prolongation of circulating) Sphingomyelin modification

PEG modification Asialoglycoprotein receptor mediated Galactose modification

Target Tissue (Cell)

Tumor

Tumor

Mannose receptor mediated

Mannose modification

Liver (hepatocyte)

Liver (non-parenchymal cell)

Reference

45 53

59 62

64 61

66 67 71

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