Liposomes As Boron Delivery Agents 661 Overview of Liposomes

Liposomes are biodegradable, nontoxic vesicles that have been used to deliver both hydrophilic and hydrophobic agents (Figure 6.6).97 Both classical and PEGylated ("stealth") liposomes can increase the amounts of anti-cancer drugs that can be delivered to solid tumors by passive targeting. Rapidly growing solid tumors have increased permeability to nanoparticles due to increased capillary pore size. These can range from 100 to 800 nm. In comparison, endothelial pore size of normal tissues, which are impermeable to liposomes, can range in size from 60 to 80 nm. In addition, tumors lack efficient lymphatic drainage, and consequently, clearance of extravasated liposomes is slow.98 Modification of the liposomal surface by PEGylation or attachment of antibodies or receptor ligands, will improve their selective targeting and increase their circulation time.98

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