Mr Imaging Of Paramagnetic Hpma Copolymer Conjugates

N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer is a biocompatible water-soluble polymeric carrier for therapeutics.1 The conjugation of anti-cancer drugs to HPMA copolymers results in many advantageous features over small molecular therapeutics, including improved water solubility and bioavailability, preferential accumulation of the conjugates in solid tumors, reduced nonspecific toxicity, and down-regulation of multi-drug resistance.1,29 A number of HPMA copolymer drug conjugates have been systematically investigated both in vitro and in vivo. Several HPMA copolymer-anti-cancer drug conjugates are now in various phases of clinical development for cancer treatment.30 The incorporation of MRI contrast agents into HPMA copolymer conjugates allows direct visualization of real-time drug delivery of the conjugates in animal models with contrast-enhanced MRI. The noninvasive imaging reveals some interesting features of drug delivery with the conjugates that cannot be obtained with conventional surgery based evaluations.

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