Mr Imaging Of Paramagnetic PolylGlutamic Acid Conjugates

Poly(l-glutamic acid) (PGA) is a negatively charged, biocompatible polymer that has been used as a carrier for drug delivery.36 It is a homopolymer of l-glutamic acid linked through peptide bonds and the pendant g-carboxyl groups are suitable to load therapeutic agents via chemical conjugation. Several poly(l-glutamic acid)-anti-cancer drug conjugates have been developed for cancer treatment.37-39 The conjugation of a MRI contrast agent to PGA enables noninvasive investigation of its pharmacokinetics and in vivo drug delivery with contrast-enhanced MRI.

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