Polymeric micelles prepared from cationic copolymer could be a novel gene carrier. After preparing a pDNA complex (standard size 5,000-7,000 bp), the mean particle of the complex is about 50-200 nm. pDNA entrapped in polymeric micelles is highly resistant to nuclease degradation.28

Dendrimers are also an attractive carrier for gene delivery because they can interact on an electrostatic charge basis with biologically relevant polyanions such as nucleic acids86 and pDNA87 because their surfaces are covered with primary amino groups. Moreover, chemical or biological modification of the surface of dendrimers would make them more effective drug or gene carriers.

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