Prostate Specific Membrane Antigen

Prostate specific membrane antigen (PSMA) encodes a folate carboxypeptidase. Its expression is tightly restricted to prostate acinar epithelium and is increased in prostatic intraepithelial neoplasia, prostatic adenocarcinoma, and in tumor-associated neovasculature. Two 2'-flouropyrimidine RNA aptamers, named xPSM-A9 and xPSM-A10, against the extracellular domain of the PSMA have been isolated and characterized.58 The aptamer xPSM-A9 inhibits the enzymatic function of the PSMA noncompetitively with a Ki = 2.1 nmol, and aptamer xPSM-A10 inhibits the enzymatic function of PSMA competitively with a Ki = 11.9 nmol. Aptamer xPSM-A10 has also been truncated from 71 nucleotides to its current size of 56 nucleotides (~ 18kD).

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