Nanotechnology and Cancer 1

Chapter 1 Introduction and Rationale for Nanotechnology in Cancer Therapy 3

Fredika M. Robertson and Mauro Ferrari

Chapter 2 Passive Targeting of Solid Tumors: Pathophysiological Principles and Physicochemical Aspects of

Delivery Systems 11

Chapter 3 Active Targeting Strategies in Cancer with a Focus on

Potential Nanotechnology Applications 19

Randall J. Mrsny

Chapter 4 Pharmacokinetics of Nanocarrier-Mediated

Drug and Gene Delivery 43

Yuriko Higuchi, Shigeru Kawakami, and Mitsuru Hashida

Chapter 5 Multifunctional Nanoparticles for Cancer Therapy 59

Todd J. Harris, Geoffrey von Maltzahn, and Sangeeta N. Bhatia

Chapter 6 Neutron Capture Therapy of Cancer: Nanoparticles and High Molecular Weight Boron Delivery Agents 77

Gong Wu, Rolf F. Barth, Weilian Yang, Robert J. Lee, Werner Tjarks, Marina V. Backer, and Joseph M. Backer

Chapter 7 Preclinical Characterization of Engineered Nanoparticles

Intended for Cancer Therapeutics 105

Anil K. Patri, Marina A. Dobrovolskaia, Stephan T. Stern, and Scott E. McNeil

Chapter 8 Nanotechnology: Regulatory Perspective for Drug

Development in Cancer Therapeutics 139

N. Sadrieh and T. J. Miller Section 2

Polymer Conjugates 157

Chapter 9 Polymeric Conjugates for Angiogenesis Targeted Tumor

Imaging and Therapy 159

Amitava Mitra, Anjan Nan, Bruce R. Line, and Hamidreza Ghandehari

Chapter 10 Poly(L-Glutamic Acid): Efficient Carrier of Cancer Therapeutics and

Diagnostics 185

Guodong Zhang, Edward F. Jackson, Sidney Wallace, and Chun Li

Chapter 11 Noninvasive Visualization of In Vivo Drug Delivery of Paramagnetic Polymer Conjugates with MRI 201

Zheng-Rong Lu, Yanli Wang, Furong Ye, Anagha Vaidya, and Eun-Kee Jeong Section 3

Polymeric Nanoparticles

Chapter 12 Polymeric Nanoparticles for Tumor-Targeted Drug


Tania Betancourt, Amber Doiron, and Lisa Brannon-Peppas

Chapter 13 Long-Circulating Polymeric Nanoparticles for Drug and

Gene Delivery to Tumors

Sushma Kommareddy, Dinesh B. Shenoy, and Mansoor M. Amiji

Chapter 14 Biodegradable PLGA/PLA Nanoparticles for Anti-cancer


Sanjeeb K. Sahoo and Vinod Labhasetwar

Chapter 15 Poly(Alkyl Cyanoacrylate) Nanoparticles for Delivery of Anti-Cancer Drugs

R. S. R. Murthy and L. Harivardhan Reddy

Chapter 16 Aptamers and Cancer Nanotechnology

Omid C. Farokhzad, Sangyong Jon, and Robert Langer

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