Sialyl Lewis X

Sialyl Lewis X (sLex) is a tetra saccharide glycoconjugate of transmembrane proteins that acts as a ligand for the selectin proteins during cell adhesion and inflammation. The sLex is also abnormally overexpressed on the surface of cancer cells and may play a role in cancer cell metastasis. An RNA aptamer referred to as clone 5 has been isolated and shown to bind to the sLex with sub-nanomolar affinity and block the sLex/selectin mediated adhesion of HL60 monocytic cell line in vitro.65 The future use of clone 5 for in vivo targeted delivery applications may require post-SELEX optimization of this aptamer, including nuclease stabilization and size minimization.

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