Some Ligands and Their Target Receptors with Potential for Targeted Delivery to Tumor Angiogenesis

Target Targeting Liganda Reference aVß3 integrin RGD 53

Aminopeptidase N (CD13) NGR 54

Vascular endothelial growth factor Anti-VEGF antibody (Bevacizumab) 13

aVß3 integrin Anti-aVß3 integrin antibody (Vitaxin) 193

MMP-2 and MMP-9 HWGF 73

Aminopeptidase A CPRECESIC 67

Cell surface nucleolin F3 (N-terminal fragment of human high 194, 195

mobility group protein 2)

Heparan sulfates CGKRK, CDTRL 196

Unknown SMSIARL 197

Kallikrein-9 CSRPRRSEC 196

Platelet-derived growth factor receptor-ß CRGRRST 198

a Single amino acid codes for peptides (see list of abbreviations at end of chapter for details).

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