Synthesis And Properties Of Pg

PG anti-cancer drug conjugates consist of three parts: the PG backbone, the anti-cancer drug, and spacers that link the drug molecules with the PG backbone. Both the properties of PG (i.e., the molecular weight and its distribution) and the selection of spacers can directly affect the pharma-cokinetics at both the whole-body and cellular level. For this reason, the synthetic chemistry of the preparation of PG will first be discussed. A summary of the physicochemical properties of PG conjugates will follow.

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