Synthesis Of PeobPlaa Block Copolymers

The traditional method for the synthesis of PLAA relies on the ring-opening polymerization (ROP) of a-amino acid-N-carboxyanhydrides (NCAs) (Figure 18.1).42 NCAs can be pre-prepared from a-amino acids using a solution of phosgene in THF by the Fuchs-Farthing method.43,44 NCA polymerization can be initiated with different nucleophiles or bases, the most common being primary amines and alkoxide anions.45-48 This synthetic method is appealing to the pharmaceutical industry because it involves simple reagents, and it is economical; high molecular weight polymers can be prepared in both good yield and large quantity by this method.

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