Targeting Using Vascular Endothelial Growth Factor Receptors

Vascular endothelial growth factor (VEGF) is particularly important in the process of angiogenesis and has been shown to greatly affect tumor growth in animal models.26-28 The VEGF receptors have been used as a means to target the vascular bed in many instances. VEGF receptor-2 (VEGFR-2) has recently been used to target nanoparticles to tumor vascular beds by Li et al in mice with K1735-M2 tumors.29 A succinyl-dextran-polymerized nanoparticle conjugated to rat anti-mouse VEGFR-2 antibody and radioisotope 90Y caused a significant tumor growth delay compared to conventional radiolabeled antibody and other controls. Additionally, anti-CD31 staining showed a decreased vessel density and damage to tumor vessels after treatment with the anti-VEGFR-2-90Y nanoparticles.

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