Toxicity Pharmacokinetics and Anti Cancer Efficacy of Drugs Formulated in Block Copolymer Micelles

As previously discussed, various micelle-based formulations have been demonstrated, in both preclinical and clinical studies, to decrease the toxicity and increase the efficacy of the encapsulated agents.16,82,90,148 To date, two of the drugs that have been most commonly formulated in block copolymer micelles are doxorubicin and paclitaxel (Figure 17.3). A general description and overview of both the doxorubicin and paclitaxel formulations in clinical development has been given in Section 17.3. At present, there are two micelle formulations of doxorubicin (i.e., SP1049C and NK911) and two of paclitaxel (Genexol-PM and NK105) that are in clinical trial development.

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