VEGF and VEGF Receptors

VEGF has become one of the most important targets for antivascular therapy. It is an endothelial cell-specific mitogen that is a potent inducer of angiogenesis. It stimulates endothelial cell growth and acts through a family of closely related receptor tyrosine kinases, the most important of which is VEGFR-2.36,57,58 VEGF receptor inhibitors have been shown to have anti-tumor effects.59,60 The most clinically developed is a humanized anti-VEGF antibody (Bevacizumab) that has been approved by the U.S. Food and Drug Administration as a first-line therapy for metastatic colorectal cancer.13

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