Nanotechnology and Our Energy Challenge

I've increasingly begun to believe that a grand challenge before usthe world and humanityis what I call the terawatt challenge. I've been looking into the energy issue and I've been on a quest for terawatts, or trillions of watts of electricity. What I'm looking for is to solve what I believe is the most important problem facing humanity, the problem of generating energy of the magnitude that we will need in this century for what could very well turn out to be ten billion people on the planet....

Nanotechnology Startup Companies

Nanotechnology start-up companies should not expect to defy fundamental business principles, as did the Internet companies of the mid- to late 1990s, if only for a brief period. Nanotechnology companies should expect to be measured by standard metrics and to confront the same industry dynamics and fundamental business issues (for example, personnel choices, sales strategy, highvolume manufacturing, efficient allocation of capital, marketing, execution of their business model, time-to-market...

Technology Exponentials

Despite a natural human tendency to presume linearity, accelerating change from positive feedback is a common pattern in technology and evolution. We are now crossing a threshold where the pace of disruptive shifts is no longer intergenerational instead, it begins to have a meaningful impact over the span of careers and eventually over product cycles. As early-stage venture capitalists (VCs), we look for disruptive businesses run by entrepreneurs who want to change the world. To be successful,...

Concept 1 Lessons From the SCurve

The first concept is that of the S-curve. Introduced by Richard Foster, the S-curve describes the relationship between the investment of resources in a technology or process and the resulting performance produced by that investment (Figure 1-1).UH It is referred to as an S-curve because when the results are plotted, the resulting figure typically takes the shape of the letter S. Figure 1-1. An example of an S-curve. Figure 1-1. An example of an S-curve. In an early stage, as effort is ramping...

Nanoparticles for Drug Delivery

Nanoparticle-based delivery vehicles improve drug efficacy by modulating drug pharmocokinetics and biodistribution. Small-molecule drugs are rapidly eliminated from the circulation by the kidneys. Injectable nanoparticledelivery vehicles, typically ranging from 5nm to 200nm in size, substantially increase circulation (particles > 5nm avoid kidney clearance) while minimizing removal by cells that police the blood for foreign particles (macrophages have less propensity for particles < 200nm...