Therapeutic Microsystems

Therapeutic microsystems are designed to alleviate certain symptoms and help in the treatment of a disease. In this category, we will describe two such microsystems. The first one is a drug delivery microchip designed to administer small quantities of potent drugs upon receiving a command signal from the outside. The second device is a passive micromachined glucose transponder, which can be used to remotely monitor glucose fluctuations allowing a tighter blood glucose control through frequent measurements and on-demand insulin delivery (pump therapy or multiple injections)

Figure 10.5 shows the central component of the drug delivery microchip [52, 53]. It consists of several micro-reservoirs (25 nl in volume) etched in a silicon substrate. Each micro-reservoir contains the targeted drug and is covered by a thin gold membrane (3000 A), which can be dissolved through the application of a small voltage (1V vs. SCE), Figure 10.5. The company marketing this technology (MicroCHIPS Inc.) is in the process of designing a wireless transceiver that can be used to address individual wells and release the drug upon the reception of the appropriate signal [54]. Another company (ChipRx Inc.) is also aiming to develop a similar microsystem (Smart Pill), Figure 10.6 [55]. Their release approach however is different and is based on conductive polymer actuators acting similar to a

Microsystems For Insulin Delivery Suisse

FIGURE 10.5. MicroCHIP drug delivery chip (top), a reservoir before and after dissolution of the gold membrane (bottom) [52].



Control Circuitry Biosensor mm

Drug Release Holes

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook

Post a comment