PVC membranes doped with TPP and MnTPPCl were used to develop an optical fiber optic sensor for the determination of berberine, an anti-inflammatory drug for the heart . The sensing mechanism was based on the fluorescence quenching of TPP-MnTPPCl operated by berberine. The sensor operated in the 7.5 x 10-7 to 5.6 x 10-4 mol/L working range of berberine concentration, with fast response time and fair selectivity toward common interfering species. The exploitation of the TPP-MnTPPCl mixture gave better results than the use of the simple TPP.
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