Polyisobutylcynoacrylate Nanocapsules

Intragastric administration of insulin-loaded poly(isobutyl-cyanoacrylate) nanocapsules induced a reduction of the glycemia to normal level in streptozotocin diabetic rats

[80] and alloxan induced diabetic dogs [81]. The hypol-glycemic effect was characterized by surprising events including a lag time period of 2 days and a prolonged effect over 20 days. Insulin is a very hydrosoluble pep-tide and should be inactivated by the enzymes of the gastrointestinal tract. Thus, that insulin could be encapsulated with high efficiency in nanocapsules containing an oily core and why these nanocapsules showed so unexpected biological effect remained unexplained. Nanocapsules were prepared by interfacial polymerization of isobutylcyanoacrylate [82]. Any nucleophilic group including those of some of the aminoacids of insulin [83] could initiate the polymerization of such a monomer. In this case, insulin could be found covalently attached to the polymer forming the nanocap-sule wall as was recently demonstrated with insulin-loaded nanospheres [84].

Aboubakar et al. [85] studied physicochemical characterization of insulin-loaded poly(isobutyl cyanoacrylate) nanocapsules obtained by interfacial polymerization. They claimed that the large amount of ethanol used in the preparation of the nanocapsules that initiated the polymerization of isobutylcyanoacrylate preserved the peptide from a reaction with monomer resulting in a high encapsulation rate of insulin. From their investigations, it appears that insulin was located inside the core of the nanocapsules and not simply adsorbed onto their surface.

Lambert et al. [86] used poly(isobutyl cyanoacrylate) nanoparticles for the delivery of oligonucleotides. Nanopar-ticles of size ranging from 20 to 400 nm were prepared. The authors claimed that this technology might offer interesting perspectives for DNA and peptide transport and delivery.

CH3(OC2H4)n NHCO

CH3 CH3

CHO(COCHO)m 1COCHOH HO) COCHOH

CHO(COC

CH3(OC2H4)n NHCO

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