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b) magnetic capture c) bead dissolution

Fig. 15.9 (a) Amplified detection of DNA by using nucleic acid-Au nanoparticles-functionalized beads as labels and electroless catalytic deposition of gold on the nanoparticles as a means of amplification: (a) Hybridization of the nucleic acid-Au nanoparticles-functionalized beads with the target DNA, which is associated with a magnetic bead; (b) The enhanced catalytic deposition of gold on the nanoparticles; (c) Dissolution of the gold clusters; (d) The detection of the Au3+ ions by stripping voltammetry. (Reprinted with permission from [74]; copyright Wiley-VCH publications) (b) Amplified detection of DNA with polystyrene beads, which are loaded with a ferrocene redox marker 64. (Reprinted with permission from [75]; copyright ACS publications)

b) magnetic capture c) bead dissolution

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