To achieve interfacial polymerization, monomers are polymerized at the interface between two immiscible phases. Interfacial polymerization takes place in a medium consisting of an aqueous and an organic phase, which are homogenized, emulsified, or micro-fluidized by vigorously mechanical stirring. Al Kouhri Fallouh et al.  introduced the formation of polyalkylcyanoacrylate nanocapsules. In this process the monomer and the drug are dissolved in a mixture of oil and ethanol (oil/ethanol: to jgg) and then slowly added through a small tube or needle to an aqueous phase containing surfactants (poloxamer 188 or 407 or phospholipids). The oil used can be Miglyol or benzylic acid. The primary disadvantage of this method is the occurrence of strong shear forces. This excludes the possibility of adding proteins and peptides during the polymerization process for incorporation purposes. The monomer spontaneously polymerizes and forms nanocapsules that consist of an oil droplet and a polymeric shell . An advantage of this process is that the drug is encapsulated into the nanocapsule and not just adsorbed onto the surface. This would protect it from enzymes, thus preventing premature biodegradation before it reaches the blood brain barrier.
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