Detection And Characterization Of The Peg Corona

All the copolymers listed in Figure 1 are amphiphilic, consisting of hydrophilic PEG blocks and hydrophobic PLA, PLGA, PCL, poly(sebacic acid) (PSA), or PACA blocks. These blocks have different affinities for the organic and aqueous phases that are put in contact in the preparation methods previously described. Therefore, it generally is assumed that these blocks would migrate preferentially toward the aqueous phase (PEG) or the organic phase (hydrophobic block) during the nanoparticle preparation, leading, after solvent evaporation, to the formation of core(hydrophobic polymer)-shell(PEG) nanoparticles [9, 43-45]. Different configurations (Fig. 2) would thus be obtained: (i) "brush" with diblock (PEG-R) or multiblock (PEG-PACA) copolymers, (ii) "loops" using triblock R-PEG-R copolymers, (iii) "bunch" with R-PEG3 copolymers, and (iv) "star" PEG using the "star" copolymers previously described [48]. In practice, the presence of the PEG coating on the nanoparticles was evidenced by "direct" and "indirect" techniques.

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