Glossary

Complement System of proteins in the blood, which act in series by the classical or the alternative pathways, to produce a variety of biological effects. The classical pathway consists of nine separate components, of which C1 to C5 are enzymes in an inactive form. The most important products of the enzyme cascade are C3b, C3a, and C5a, which aid engulfment and killing of microbes by phagocytic cells and initiate inflammatory reactions.

Kupffer cell Macrophages which line the blood sinuses of the liver. They are phagocytic and effectively remove foreign particles from the blood.

Macrophage Cell of the mononuclear phagocyte system, derived from blood monocytes which migrate into tissues and differentiate there.

Mononuclear phagocyte system Phagocytic cells derived from bone marrow promonocytes, having the ability to ingest and digest particulate materials, and to express the receptors characteristic of macrophages. Macrophages in the lung, the peritoneal cavity or in the lymph are free to migrate, whereas macrophages such as Kupffer cells or osteoclasts remain in-situ for long periods of time. Nanocapsules Nanoparticles with an oily or aqueous core, containing most of the drug dissolved, and surrounded by a polymeric coating.

Nanoparticle Solid colloidal particle ranging in size from 10 to 1000 nm, consisting of macromolecular materials in which the active principle is dissolved, entrapped, encapsulated, or to which the drug is adsorbed or attached. Nano-capsules are divided in nanospheres and nanocapsules. Nanospheres Nanoparticles with a polymeric core. Opsonin Factor present in blood and other body fluids, which bind to particles and increase their susceptibility to phagocytosis.

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