High pressure homogenization Method for the preparation of SLN and NLC. High shear forces and cavitation in a piston-gap homogenizer lead to particle diminution.

In vitro tolerability Method using cell cultures to assess potential toxic effects. Measures of in vitro tolerability include viability of cells, Interleukin 6 and 12 and TNF-a production.

Nanostructured lipid carriers (NLC) Nanoparticles composed of a mixture of lipids solid or liquid at room (body) temperature. The mixture allows higher drug incorporation. Scaling up Increasing the batch size from lab scale to large scale while ensuring identical batch characteristics. Solid lipid nanoparticles (SLN) Nanoparticles with a matrix composed of lipids solid at room (body) temperature. Versatile drug carrier system.

Supersaturated systems Used for increased penetration of drugs. By creating a supersaturated system, the thermody-namic activity is increased promoting penetration.

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