Central Nervous System Injury

The lack of tissue regeneration in the CNS is due to a complex series of events that follow injury. Though these events are necessary for the restoration of the blood-brain barrier and minimization of secondary tissue damage, they also result in the formation of an environment which is not conducive to tissue regeneration. Damage to the CNS initiates an astrocytic response resulting in a glial scar. Damaged tissue releases molecular cues which promote astrocytic glial cell activity....