Biodegradable Metals and Responsive Biosensors for Musculoskeletal Applications

Huinan Liu

Abstract Expenditures in musculoskeletal injuries and diseases are projected to continuously increase due to the aging population and the change of lifestyles. The development of effective biomaterials and novel devices for musculoskeletal applications are one of the most important tasks of biomedical research. This chapter will introduce hard and soft tissues in the human musculoskeletal system. The physiochemical and mechanical properties of natural bone and ligaments will be reviewed so as to design novel biomaterials and devices to repair or regenerate these tissues. Biomaterials, including metals, ceramics and polymers, used for the repair and regeneration of bone and ligament tissues will be discussed. Recent research efforts and renewed interests in developing resorbable metallic biomaterials such as magnesium (Mg) alloys for orthopedic and craniofacial applications will be highlighted. Lastly, growing clinical interests in the development of responsive biosensors for orthopedic/craniofacial applications will be discussed.

Keywords Biomaterials • Biodegradable metals • Magnesium alloys • Biosensors • Musculoskeletal applications • Orthopedic applications

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