Bone Marker Biosensors

Bone marker sensing and correlation with bone regeneration have attracted much attention in recent decades (Yun et al. 2007). The development of electronic biosensors to detect bone markers in solutions has been reported (Yun et al. 2009). Briefly, a label-free immunosensor for bone maker detection in solutions outside the body has been tested. A self-assembled monolayer (SAM) of dithiodipropi-onic acid was deposited on a gold electrode. Then, a streptavidin biotinylated antihuman C-terminal telopeptide antibody was conjugated on the SAM. Subsequently, EI was measured with different concentrations of the C-terminal telopeptide.

Resistance to degradation in the physiological environment can be evaluated experimentally by measuring the current density at the corrosion potential in an electrochemical polarization curve. Better corrosion resistance gives lower corrosion current densities. As the implant degrades, Mg forms a partially passive coating and degradation continues. The volume of Mg decreases as bone cells form on the implant. During this process, the electrical impedance of the implant changes because of the formation of a passive layer, the decrease in the volume of Mg, and the attachment of bone cells on the implant. The passive layer and bone cells attaching to the implant will affect the sensor's electron transfer resistance. This relationship can be modeled mathematically to better describe implant degradation and bone formation processes simultaneously.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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