Vascularization Process in Tumors Angiogenesis

Angiogenesis is the growth of new blood vessels from preexisting blood vessels. Angiogenesis can occur from circulating endothelial precursors, shed from the vessel wall or mobilized from the bone marrow. Angiogenesis starts with peri-cytes retractring from the abluminal surface of capillaries. After that, endothelial cells release and activate proteases (such as urokinase (uPA), progelatinase A, progelatinase B, etc.) that degrade the extracellular matrix surrounding the existing capillaries. Endothelial cells then migrate, proliferate, and align to form tube-like structures, which ultimately anastomose to form new capillaries (Eatock et al. 2000). Cancer treatment strategies aiming at attacking angiogenesis in tumors can focus on any of those angiogenic stages.

Was this article helpful?

0 0
Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

Get My Free Ebook


Post a comment